Hypothyroxinaemia Psychomotor development Thyroid function
Fecha de publicación:
Suarez Rodriguez M, Azcona San Julian C, Alzina de Aguilar V. Influencia de la hipotiroxinemia materna durante la gestación sobre el desarrollo psicomotor. An Pediatr (Barc) 2008 Nov;69(5):420-425.
The maternal thyroid function during early pregnancy
plays a fundamental role in foetal brain development as
synthesis of thyroid hormone does not begin until the 20th
week of gestation.
Material and methods
Throughout the year 2002, 147 women in their 37th week
of pregnancy were enrolled for the study. To evaluate their
thyroid function, the serum concentrations of free T4 and
of TSH were determined. After birth, the psychomotor development
of their children was evaluated with the Mc-
The median value of free T4 was 9.37 pmol/l, being the
data obtained from more than half of the sampled women
below the hypothyroxinaemia threshold. Children born
from mothers with T4 levels below percentile 10 showed a
significantly lower score on the general cognitive index
than those whose mothers had normal free T4 serum concentrations.
A positive correlation was found between the
values of maternal free T4 and the general cognitive index
(r 0.43; p < 0.01).
The concentrations of maternal free T4 are important, not
only during the first months of pregnancy, but all along the
process to ensure adequate development of the foetal brain.