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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Ciencias Cardiovasculares > Enfermedad vascular hipertensiva > DA - CIMA - Cardiovasculares - Enfermedad vascular - Artículos de Revista >

Blockade of TGF-β 1 Signalling Inhibits Cardiac NADPH Oxidase Overactivity in Hypertensive Rats
Authors: Miguel-Carrasco, J.L. (José Luis)
Baltanas, A. (Ana)
Cebrian, C. (Carolina)
Moreno, M.U. (María Ujué)
Lopez, B. (Begoña)
Hermida, N. (Nerea)
Gonzalez, A. (Arantxa)
Dotor, J. (Javier)
Borras-Cuesta, F. (Francisco)
Diez, J. (Javier)
Fortuño, A. (Ana)
Zalba, G. (Guillermo)
Keywords: Cardiac NADPH oxidase
TGF-beta 1
Hypertensive rats
Issue Date: 2012
Publisher: Hindawi
Publisher version:
ISSN: 1942-0994
Citation: Miguel-Carrasco JL, Baltanas A, Cebrian C, Moreno MU, Lopez B, Hermida N, et al. Blockade of TGF-beta 1 Signalling Inhibits Cardiac NADPH Oxidase Overactivity in Hypertensive Rats. Oxid Med Cell Longev 2012;2012:726940.
NADPH oxidases constitute a major source of superoxide anion (·O(2) (-)) in hypertension. Several studies suggest an important role of NADPH oxidases in different effects mediated by TGF-β 1. In this study we show that chronic administration of P144, a peptide synthesized from type III TGF-β 1 receptor, significantly reduced the cardiac NADPH oxidase expression and activity as well as in the nitrotyrosine levels observed in control spontaneously hypertensive rats (V-SHR) to levels similar to control normotensive Wistar Kyoto rats. In addition, P144 was also able to reduce the significant increases in the expression of collagen type I protein and mRNA observed in hearts from V-SHR. In addition, positive correlations between collagen expression, NADPH oxidase activity, and nitrotyrosine levels were found in all animals. Finally, TGF-β 1-stimulated Rat-2 exhibited significant increases in NADPH oxidase activity that was inhibited in the presence of P144. It could be concluded that the blockade of TGF-β 1 with P144 inhibited cardiac NADPH oxidase in SHR, thus adding new data to elucidate the involvement of this enzyme in the profibrotic actions of TGF-β 1.
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Appears in Collections:DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista
DA - CIMA - Terapia génica y Hepatología - Inmunología experimental - Artículos de revista
DA - CUN - Cardiología - Artículos de revista
DA - CIMA - Cardiovasculares - Enfermedad vascular - Artículos de Revista

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