Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Paloma, M.J. (María José) | - |
dc.creator | Paramo, J.A. (José Antonio) | - |
dc.creator | Rocha, E. (Eduardo) | - |
dc.date.accessioned | 2012-07-06T07:37:39Z | - |
dc.date.available | 2012-07-06T07:37:39Z | - |
dc.date.issued | 1995 | - |
dc.identifier.citation | Paloma MJ, Paramo JA, Rocha E. Endotoxin-induced intravascular coagulation in rabbits: effect of tissue plasminogen activator vs urokinase of PAI generation, fibrin deposits and mortality. Thromb Haemost 1995 Dec;74(6):1578-1582. | es_ES |
dc.identifier.issn | 0340-6245 | - |
dc.identifier.uri | https://hdl.handle.net/10171/22847 | - |
dc.description.abstract | We have evaluated the effect of plasminogen activators (t-PA and urokinase) on an experimental model of disseminated intravascular coagulation (DIC) in rabbits by injection of 20 micrograms/kg/h of E. coli lipopolysaccharide during 6 h t-PA (0.2 mg/kg and 0.7 mg/kg), urokinase (3000 U/kg/h) and saline (control) were given simultaneously with endotoxin. Results indicated that urokinase and low dose of t-PA significantly reduced the increase of plasminogen activator inhibitor (PAI) activity observed 2 h after endotoxin (p < 0.001). High t-PA dose also diminished the PAI levels at 6 h (p < 0.001). A significant reduction of fibrin deposits in kidneys was observed din both t-PA treated groups as compared with findings in the group of rabbits infused with saline solution (p < 0.005), whereas urokinase had no significant effect on the extent of fibrin deposition. Finally, the mortality rate in the control group (70%) was reduced to 50% in rabbits receiving high doses of t-PA. In conclusion, treatment with t-PA resulted in reduced PAI generation, fibrin deposits and mortality in endotoxin-treated rabbits. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Schattauer | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Disseminated intravascular coagulation/drug therapy | es_ES |
dc.subject | Fibrin/metabolism | es_ES |
dc.subject | Plasminogen activators/therapeutic use | es_ES |
dc.subject | Plasminogen inactivators/biosynthesis | es_ES |
dc.subject | Tissue plasminogen activator/therapeutic use | es_ES |
dc.subject | Urokinase-type plasminogen activator/therapeutic use | es_ES |
dc.title | Endotoxin-induced intravascular coagulation in rabbits: effect of tissue plasminogen activator vs urokinase of PAI generation, fibrin deposits and mortality | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
Files in This Item:
Statistics and impact
Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.