Aspirin, non-aspirin analgesics and the risk of hypertension in the SUN cohort.
Otros títulos : 
La aspirina, analgésicos sin aspirina y el riesgo de hipertensión arterial en la cohorte de SUN
Palabras clave : 
Anti-Inflammatory agents, Non-steroidal/adverse effects
Aspirin/adverse effects
Hypertension/chemically induced/epidemiology
Fecha de publicación: 
2010
Editorial : 
Elsevier España
ISSN: 
0300-8932
Cita: 
Beunza JJ, Martinez-Gonzalez MA, Bes-Rastrollo M, Nunez-Cordoba JM, Toledo E, Alonso A. Aspirin, non-aspirin analgesics and the risk of hypertension in the SUN cohort. Rev Esp Cardiol 2010 Mar;63(3):286-293.
Resumen
The use of aspirin and non-aspirin analgesics has been associated with changes in blood pressure. The aim of this study was to investigate prospectively the association between the regular use of aspirin and non-aspirin analgesics and the incidence of hypertension. METHODS: The SUN project is an ongoing, continuously expanding, prospective cohort of Spanish university graduates initially free of hypertension, cardiovascular disease, diabetes and cancer; 9986 (mean age 36 years) were recruited during 1999-2005 and followed up for a mean of 51 months. Regular aspirin and non-aspirin analgesic use and the presence of other risk factors for hypertension were assessed by questionnaire at baseline, and the incidence of hypertension was assessed using biennial follow-up questionnaires. RESULTS: In total, 543 new cases of hypertension were identified during follow-up. Regular aspirin use (i.e. 2 or more days/week) was associated with a higher risk of hypertension (hazard ratio=1.45; 95% confidence interval, 1.02-2.04) after adjustment for various confounding factors. Regular use of non-aspirin analgesic drugs was also associated with a higher risk of hypertension (hazard ratio=1.69; 95% confidence interval, 1.28-2.23). CONCLUSIONS: The regular use of aspirin and non-aspirin analgesics were both associated with an increased risk of developing hypertension, independently of other risk factors.

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Fichero: 
Rev Esp Cardiol. 2010.. 286.pdf
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110,32 kB
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Adobe PDF


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