Estabilización de la placa de ateroma: un nuevo concepto basado en la biología dinámica de la aterosclerosis
Keywords: 
Aterosclerosis
Estabilización de la placa
Técnicas no invasivas de imagen vascular
Estrategias antiateroscleróticas
Issue Date: 
2003
Publisher: 
Elsevier
ISSN: 
0025-7753
Citation: 
Paramo JA, Orbe J, Rodriguez JA. Estabilización de la placa de ateroma: un nuevo concepto basado en la biología dinámica de la aterosclerosis. Med Clin (Barc) 2003 Nov 1;121(15):583-587.
Abstract
As it is well-known, a thrombus evolving into a disrupted/eroded atherosclerotic plaque causes most acute coronary syndromes. Plaque stabilization via reduction of the lipid core and/or thickening of the fibrous cap is one of the possible mechanisms accounted for the clinical benefits displayed by different anti-atherosclerotic strategies. The concept of plaque stabilization was developed to explain how lipid-lowering agents could decrease adverse coronary events without substantial modifications of the atherosclerotic lesion. A number of imaging modalities (vascular ultrasound, MRI, and coronary computed tomography) are used for non-invasive assessment of atherosclerosis; most of them can identify luminal stenosis, wall thickness and plaque volume and composition, and can even characterize the rupture-prone vulnerable plaques. Several classes of drugs, including statins, ACE inhibitors, -blockers, and antithrombotics, are able to reduce the plaque burden and the incidence of cardiovascular events; this may be attibutable, at least in part, to plaque-stabilizing effects and the improvement of endothelial dysfunction

Files in This Item:
File: 
MedClin2003_121583.pdf
Description: 
Size: 
1,64 MB
Format: 
Adobe PDF


Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.