Alegria Ezquerra E, Castellano Vazquez JM, Alegria Barrero A. Obesity, metabolic syndrome and diabetes: cardiovascular implications and therapy. Rev Esp Cardiol 2008 Jul;61(7):752-764.
Obesity, metabolic syndrome, and type-2 diabetes
mellitus are 3 interrelated conditions that share a number
of pathophysiological mechanisms and that are frequently
observed to lead, in succession, to cardiovascular
complications. The fact that their prevalence is increasing
alarmingly should prompt all healthcare professionals
urgently to implement measures to prevent these
complications. The most effective, though also the least
adopted, are those related to lifestyle modification. Drug
treatment targeted at controlling risk factors (eg,
hypertension, dyslipidemia, and thrombophilia), metabolic
abnormalities, and excess weight is also necessary.