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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Ciencias Cardiovasculares > Aterosclerosis e inflamación > DA - CIMA - Cardiovasculares - Aterosclerosis e inflamación - Artículos de revista >

Inherited haemorrhagic disease with abnormal prothrombin consumption
Autor(es) : Rocha, E. (Eduardo)
Paramo, J.A. (José Antonio)
Cuesta, B. (Braulia)
Fernandez, J. (Javier)
Palabras clave : Blood Coagulation Disorders/genetics
Prothrombin/metabolism
Fecha incorporación: 1985
Editorial : Blackwell Publishing
Versión del editor: http://bit.ly/KB1qbe
ISSN: 1365-2141
Cita: Rocha E, Paramo JA, Cuesta B, Fernandez J. Inherited haemorrhagic disease with abnormal prothrombin consumption. Br J Haematol 1985 Sep;61(1):177-184.
Resumen
The propositus is a 4-year-old boy who presented with a history of excessive bleeding after surgical procedures as well as haematomas and epistaxis. The defect in haemostasis consisted in an anomaly of the prothrombin consumption tests as the only abnormality while all the other conventional coagulation and fibrinolysis tests as well as platelet function tests were normal. The father of the propositus had no previous history of excessive bleeding but was found to have an abnormal prothrombin consumption index. The reaction to prothrombin conversion, normal at onset, slowed down to less than normal and did not reach completion until 24 h. The in vivo studies suggest that the effect does not act on the interaction between platelet phospholipid and plasma. The factor II dosage and the electrophoretic mobility of prothrombin of the plasma were normal; nevertheless when studying the purified prothrombin by means of crossed immunoelectrofocusing there appeared an anomaly of pI. This result suggests the possible existence of an abnormal prothrombin molecule responsible for a slow prothrombin conversion.
Enlace permanente: http://hdl.handle.net/10171/22925
Aparece en las colecciones: DA - Medicina - Hematología - Artículos de revista
DA - CUN - Hematología y Hemoterapia - Artículos de revista
DA - CIMA - Cardiovasculares - Aterosclerosis e inflamación - Artículos de revista

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Fichero:  BritishJHaematol1985_61177.pdf
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