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dc.creatorCatalan, V. (Victoria)-
dc.creatorGomez-Ambrosi, J. (Javier)-
dc.creatorRodriguez, A. (Amaia)-
dc.creatorSilva, C. (Camilo)-
dc.creatorRotellar, F. (Fernando)-
dc.creatorGil, M.J. (María José)-
dc.creatorÁlvarez-Cienfuegos, J. (Javier)-
dc.creatorSalvador, J. (Javier)-
dc.creatorFrühbeck, G. (Gema)-
dc.date.accessioned2012-07-27T08:07:16Z-
dc.date.available2012-07-27T08:07:16Z-
dc.date.issued2008-
dc.identifier.citationCatalán V, Gómez-Ambrosi J, Rodríguez A, Silva C, Rotellar F, Gil MJ, Cienfuegos JA, Salvador J, Frühbeck G. ,Expression of caveolin-1 in human adipose tissue is upregulated in obesity and obesity-associated type 2 diabetes mellitus and related to inflammation. Clin Endocrinol (Oxf). 2008 Feb;68(2):213-9.es_ES
dc.identifier.issn0300-0664-
dc.identifier.urihttps://hdl.handle.net/10171/22951-
dc.description.abstractCaveolin-1 (CAV-1) plays important roles in many aspects of cellular biology, including vesicular transport, cholesterol homeostasis and signal transduction. The aim of the present study was to explore gene expression levels of CAV-1 in human adipose tissue in obesity and obesity-associated type 2 diabetes mellitus (T2DM) and to analyse its potential implication in the inflammatory state associated with obesity. DESIGN AND METHODS: Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) obtained from 15 females were used in the study. Patients were classified as lean (BMI 20.8 +/- 1.0 kg/m(2)) or obese (BMI 50.5 +/- 2.6 kg/m(2)). The obese group was further subclassified as normoglycaemic (NG) or patients with T2DM. Anthropometric measurements as well as circulating metabolites, hormones and adipokines were determined. Real-time polymerase chain reaction (PCR) analyses were performed to quantify transcript levels of CAV-1 and monocyte chemoattractant protein (MCP-1). RESULTS: The presence of CAV-1 protein was detected in VAT and SAT by immunohistochemistry. Both obese NG and with T2DM patients exhibited significantly higher CAV-1 expression levels in VAT and SAT compared with lean subjects (P < 0.05). No differences between obese NG and T2DM patients were observed in VAT. However, obese T2DM patients were found to have higher CAV-1 expression levels in SAT (P < 0.05) compared with obese NG patients. A significant correlation was found between CAV-1 mRNA expression levels in VAT and different circulating inflammatory markers such as sialic acid (SA) (P < 0.001) and fibrinogen (P < 0.001) as well as with MCP1 mRNA expression (P < 0.05). CONCLUSION: Our findings show for the first time the upregulation of mRNA CAV-1 expression levels in VAT and SAT of obese NG and obese T2DM patients compared with lean controls, suggesting a role for CAV-1 in obesity and T2DM development. The association with different inflammatory markers further suggests an implication of CAV-1 in the low-grade inflammation accompanying obesity.es_ES
dc.language.isoenges_ES
dc.publisherWiley-Blackwelles_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectCaveolin 1/genetics/metabolismes_ES
dc.subjectDiabetes Mellitus, Type 2/metabolismes_ES
dc.subjectInflammation/genetics/metabolismes_ES
dc.titleExpression of caveolin-1 in human adipose tissue is upregulated in obesity and obesity-associated type 2 diabetes mellitus and related to inflammationes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.2007.03021.x/pdfes_ES
dc.type.driverinfo:eu-repo/semantics/articlees_ES

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