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dc.creatorRiezu-Boj, J.I. (José Ignacio)-
dc.creatorParker, D. (D.)-
dc.creatorCiveira, M.P. (María Pilar)-
dc.creatorPhippard, D. (D.)-
dc.creatorCorbishley, T.P. (T.P.)-
dc.creatorCamps, J. (J.)-
dc.creatorCastilla, A. (A.)-
dc.creatorPrieto, J. (Jesús)-
dc.date.accessioned2012-08-06T12:54:10Z-
dc.date.available2012-08-06T12:54:10Z-
dc.date.issued1992-
dc.identifier.citationRiezu-Boj JI, Parker D, Civeira MP, Phippard D, Corbishley TP, Camps J, et al. Detection of hepatitis C virus antibodies with new recombinant antigens: assessment in chronic liver diseases. J Hepatol 1992 Jul;15(3):309-313.es_ES
dc.identifier.issn1600-0641-
dc.identifier.urihttp://hdl.handle.net/10171/23015-
dc.description.abstractA new serological assay to detect antibodies against hepatitis C, based on a recombinant protein (BHC10) which incorporates structural and non-structural viral antigens, was tested in 67 healthy subjects and 409 patients with various forms of liver disease. Results were compared with the current assay based on the recombinant non-structural viral antigen c100 and with the recently introduced second-generation assay, Ortho2. None of the healthy subjects was positive by any of the assays. In patients with chronic non-A, non-B hepatitis the prevalence of anti-BHC10 was 96.8%, higher than anti-c100 (83.3%, p less than 0.001) and similar to Ortho2 (94.3%). False-positive results were less frequently found when BHC10 was used. These findings show that assays incorporating structural and non-structural antigens provide higher sensitivity to detect hepatitis C virus infection and they define an almost exclusive role of hepatitis C virus in the genesis of chronic non-A, non-B hepatitis.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectHCV antibodyes_ES
dc.subjectPolymerase chain reactiones_ES
dc.subjectChronic hepatitis Ces_ES
dc.subjectChronic hepatitis Bes_ES
dc.subjectAlcoholic !iver diseasees_ES
dc.subjectPrimary biliary cirrhosises_ES
dc.subjectHepatocellular carcinomaes_ES
dc.titleDetection of hepatitis C virus antibodies with new recombinant antigens: assessment in chronic liver diseaseses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/016882789290061Ses_ES
dc.type.driverinfo:eu-repo/semantics/articlees_ES

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