Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Riezu-Boj, J.I. (José Ignacio) | - |
dc.creator | Parker, D. (D.) | - |
dc.creator | Civeira, M.P. (María Pilar) | - |
dc.creator | Phippard, D. (D.) | - |
dc.creator | Corbishley, T.P. (T.P.) | - |
dc.creator | Camps, J. (J.) | - |
dc.creator | Castilla, A. (Alberto) | - |
dc.creator | Prieto, J. (Jesús) | - |
dc.date.accessioned | 2012-08-06T12:54:10Z | - |
dc.date.available | 2012-08-06T12:54:10Z | - |
dc.date.issued | 1992 | - |
dc.identifier.citation | Riezu-Boj JI, Parker D, Civeira MP, Phippard D, Corbishley TP, Camps J, et al. Detection of hepatitis C virus antibodies with new recombinant antigens: assessment in chronic liver diseases. J Hepatol 1992 Jul;15(3):309-313. | es_ES |
dc.identifier.issn | 1600-0641 | - |
dc.identifier.uri | https://hdl.handle.net/10171/23015 | - |
dc.description.abstract | A new serological assay to detect antibodies against hepatitis C, based on a recombinant protein (BHC10) which incorporates structural and non-structural viral antigens, was tested in 67 healthy subjects and 409 patients with various forms of liver disease. Results were compared with the current assay based on the recombinant non-structural viral antigen c100 and with the recently introduced second-generation assay, Ortho2. None of the healthy subjects was positive by any of the assays. In patients with chronic non-A, non-B hepatitis the prevalence of anti-BHC10 was 96.8%, higher than anti-c100 (83.3%, p less than 0.001) and similar to Ortho2 (94.3%). False-positive results were less frequently found when BHC10 was used. These findings show that assays incorporating structural and non-structural antigens provide higher sensitivity to detect hepatitis C virus infection and they define an almost exclusive role of hepatitis C virus in the genesis of chronic non-A, non-B hepatitis. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | HCV antibody | es_ES |
dc.subject | Polymerase chain reaction | es_ES |
dc.subject | Chronic hepatitis C | es_ES |
dc.subject | Chronic hepatitis B | es_ES |
dc.subject | Alcoholic !iver disease | es_ES |
dc.subject | Primary biliary cirrhosis | es_ES |
dc.subject | Hepatocellular carcinoma | es_ES |
dc.title | Detection of hepatitis C virus antibodies with new recombinant antigens: assessment in chronic liver diseases | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/016882789290061S | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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