Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Ruiz, J. (Juan) | - |
dc.creator | Sangro, B. (Bruno) | - |
dc.creator | Cuende, J.I. (J.I.) | - |
dc.creator | Beloqui, O. (Óscar) | - |
dc.creator | Riezu-Boj, J.I. (José Ignacio) | - |
dc.creator | Herrero, J.I. (José Ignacio) | - |
dc.creator | Prieto, J. (Jesús) | - |
dc.date.accessioned | 2012-08-09T11:49:47Z | - |
dc.date.available | 2012-08-09T11:49:47Z | - |
dc.date.issued | 1992 | - |
dc.identifier.citation | Ruiz J, Sangro B, Cuende JI, Beloqui O, Riezu-Boj JI, Herrero JI, et al. Hepatitis B and C viral infections in patients with hepatocellular carcinoma. Hepatology 1992 Sep;16(3):637-641. | es_ES |
dc.identifier.issn | 1527-3350 | - |
dc.identifier.uri | https://hdl.handle.net/10171/23044 | - |
dc.description.abstract | The prevalence of hepatitis B and C virus infections was studied in 70 patients diagnosed as having hepatocellular carcinoma. In addition to viral serological markers, serum hepatitis B virus DNA and hepatitis C virus RNA were determined with a nested polymerase chain reaction assay. Twelve patients (17%) were HBsAg positive, 26 (37%) had antibodies to HBs, HBc or both and 32 (46%) were negative for all hepatitis B virus serological markers. Prevalence of the antibody to hepatitis C virus was 63% (44 patients). Hepatitis B virus DNA was detected in 24 of the 66 tested patients (36%). Twelve of these hepatitis B virus DNA-positive patients were HBsAg negative (seven were positive for antibody to HBs, antibody to HBc or both and five were negative for all hepatitis B virus serological markers). Hepatitis C virus RNA was found in 42 of 68 patients (62%). A high correlation (95%) existed between hepatitis C virus RNA and hepatitis C virus antibodies. Nevertheless, two patients without antibody to hepatitis C virus had serum hepatitis C virus RNA sequences. Coinfection by the two viruses was detected in nine subjects (14%), but no clinical differences were found between these and the rest of the patients. We conclude that nearly 90% (62 of the 70 patients studied) of cases of hepatocellular carcinoma in our geographical area are related to hepatitis virus infections (detected by serological or molecular studies). Hepatitis C is more prevalent than hepatitis B virus in patients with hepatocellular carcinoma, and the infection is still active when the tumor is diagnosed. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley-Blackwell | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Carcinoma, hepatocellular/immunology | es_ES |
dc.subject | Hepacivirus/isolation and purification | es_ES |
dc.subject | Hepatitis B/immunology | es_ES |
dc.subject | Hepatitis B virus/isolation and purification | es_ES |
dc.subject | Hepatitis C/immunology | es_ES |
dc.subject | Liver neoplasms/immunology | es_ES |
dc.title | Hepatitis B and C viral infections in patients with hepatocellular carcinoma | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.1002/hep.v16:3/issuetoc | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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