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Dadun > Depósito Académico > Facultad de Farmacia > Departamento de Química Orgánica y Farmacéutica > DA - Farmacia - Orgánica - Artículos de revista >

An approach to the toxicity and toxicokinetics of aflatoxin B1 and ochratoxin A after simultaneous oral administration to fasted F344 rats
Authors: Corcuera, L.A. (Laura Ana)
Vettorazzi, A. (Ariane)
Arbillaga, L. (Leire)
Gonzalez-Peñas, E. (Elena)
Lopez-de-Cerain, A. (Adela)
Keywords: Ochratoxin A
Toxicokinetic
Simultaneous administration
Aflatoxin B1
Issue Date: 2012
Publisher: Elsevier
Publisher version: http://dx.doi.org/10.1016/j.fct.2012.06.048
ISSN: 0278-6915
Citation: Corcuera LA, Vettorazzi A, Arbillaga L, Gonzalez-Penas E, Lopez de Cerain A. An approach to the toxicity and toxicokinetics of aflatoxin B1 and ochratoxin A after simultaneous oral administration to fasted F344 rats. Food Chem Toxicol 2012 Jul 4.
Abstract
Humans are exposed to the hepatotoxic aflatoxin B1 (AFB1) and nephrotoxic ochratoxin A (OTA) through diet. However, kinetic and toxicological data after their co-administration are scarce. In this study, a single oral dose of AFB1 (0.25mg/kg bw)+OTA (0.5mg/kgbw) was administered to fasted F344 rats. Blood, liver and kidney were harvested at different timepoints for mycotoxins quantification, relative weight calculation, clinical biochemistry and histopathology analysis. Toxicity parameters pointed to acute toxicity in liver due to AFB1. No remarkable toxicity was observed in kidneys or immunological organs. Maximum observed concentrations in plasma (C(max)) were at 10min and 2h for AFB1 and OTA, respectively. AFB1 plasma concentration could indicate a rapid absorption/ metabolism of the mycotoxin; and AFB1 liver and kidney concentrations were lower than LOQ and LOD, respectively. For OTA, C(max) was 4326.2μg/L in plasma. In kidney and liver C(max) was reached at 8h and concentrations were very similar between both organs at all timepoints. Due to the low levels of AFB1, the effect of OTA on AFB1 kinetics could not be assessed. However, AFB1 seems not to affect OTA kinetics, as its profile seems very similar to kinetic studies performed only with OTA in similar conditions.
Permanent link: http://hdl.handle.net/10171/23065
Appears in Collections:DA - Farmacia - CAFT - Artículos de revista
DA - Farmacia - Orgánica - Artículos de revista

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