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Dadun > Depósito Académico > Clínica Universidad de Navarra > Radiología > DA - CUN - Radiología - Artículos de revista >

Osteosarcoma: correlation between radiological and histological changes after intra-arterial chemotherapy
Autor(es) : Bilbao, J.I. (José I.)
Martin-Algarra, S. (Salvador)
Martinez-de-Negri, J. (J.)
Lecumberri, F. (F.)
Longo, J. (J.)
Sierrasesumaga, L. (Luis)
Cañadell, J.M. (J. M.)
Palabras clave : Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Bone Neoplasms/drug therapy/pathology/radiography
Extremities/radiography
Fecha incorporación: 1990
Editorial : Elsevier
Versión del editor: http://www.sciencedirect.com/science/article/pii/0720048X90901566
ISSN: 0720-048X
Cita: Bilbao JI, Martin Algarra S, Martinez de Negri J, Lecumberri F, Longo J, Sierrasesumaga L, Cañadell J. Osteosarcoma: correlation between radiological and histological changes after intra-arterial chemotherapy. Eur J Radiol. 1990 Sep-Oct;11(2):98-103.
Resumen
The statistical correlation between three different radiological methods (conventional radiography, computed tomography and angiography) and tumor necrosis (TN) of the resected specimen have been studied in a series of 31 patients diagnosed with osteosarcoma (OS). They were treated with a multidisciplinary approach including intraarterial and intravenous chemotherapy followed by limb salvage procedures, plus intraoperative radiotherapy and adjuvant chemotherapy. A clear statistical correlation has been obtained between TN and angiography (p = 0.02) and between TN and two specific radiological signs: 'tumoral stain and neovascularity' (p = 0.02) and 'peritumoral fat planes' (p = 0.05). Conventional radiography, computed tomography and other radiological signs studied (nutrient vessel, soft tissue mass and central peripheral calcifications) did not show any significant correlation with TN. These results seem to suggest that angiography is a method to evaluate TN preoperatively and also to define the efficacy of neoadjuvant chemotherapy in OS.
Enlace permanente: http://hdl.handle.net/10171/23153
Aparece en las colecciones: DA - CUN - Pediatría - Artículos de revista
DA - CUN - Cirugía ortopédica y traumatología - Artículos de revista
DA - CUN - Oncología médica - Artículos de revista
DA - CUN - Radiología - Artículos de revista

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Fichero:  Eur.J Radiol.1990.98..pdf
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Tamaño:  2,93 MB
Formato:  Adobe PDF
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