Colon cancer eradication after chemoimmunotherapy is associated with intratumoral emergence of proinflammatory myeloid cells
Keywords: 
Interleukin-12
Cyclophosphamide
Colorectal cancer
Inflammatory myeloid cells
Issue Date: 
2012
Publisher: 
Landes Bioscience
ISSN: 
2162-402X
Citation: 
Medina-Echeverz J, Berraondo P. Colon cancer eradication after chemoimmunotherapy is associated with intratumoral emergence of proinflammatory myeloid cells. Oncoimmunology 2012 Jan 1;1(1):118-120.
Abstract
Interleukin-12 immune stimulation lacks efficacy in established solid tumor models. Disruption of tumor microenvironment homeostasis by low-dose cyclophosphamide prior to interleukin-12 gene therapy led to CD8+ T cell-driven established tumor rejection. This only takes place when inflammatory myeloid cells infiltrate the tumor bed, and is crucial for the latter antitumor response.

Files in This Item:
File: 
OncoImmunol2012_1_1_118.pdf
Description: 
Size: 
518,92 kB
Format: 
Adobe PDF


Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.