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Dadun > Depósito Académico > Clínica Universidad de Navarra > Cirugía general y digestiva > DA - CUN - Cirugía general y digestiva - Artículos de revista >

Comparison Between Two Warm Ischemic Models in Experimental Liver Transplantation in Pigs
Authors: Martinez-Regueira, F. (Fernando)
Espi, A. (A.)
Nwose, P. (P.)
Diez-Caballero, A. (Alberto)
Baixauli, J. (Jorge)
Rotellar, F. (Fernando)
Olea, J. (J.)
Pardo, F. (Fernando)
Hernandez-Lizoain, J.L. (Jose Luis)
Cienfuegos, J.A. (Javier A.)
Keywords: Liver/cytology/pathology
Liver Transplantation/physiology
Organ Preservation/methods
Issue Date: 2003
Publisher: Elsevier
Publisher version:
ISSN: 0041-1345
Citation: Regueira FM, Espí A, Nwose P, Díez-Caballero A, Baixaulí J, Rotellar F, Olea J, Pardo F, Hernández-Lizoain JL, Cienfuegos JA. Comparison between two warm ischemic models in experimental liver transplantation in pigs. Transplant Proc. 2003 Jun;35(4):1591-3.
Experimental models of warm ischemia in liver transplantation have been employed to study the mechanisms and treatment of ischemia reperfusion injury. METHODS: We compared a control group without (group A, n = 10) versus two models of warm ischemia of liver transplants in pigs: namely, occlusion of the hepatic artery and portal vein for 30 minutes (group B, n = 23) and extraction of the liver 60 minutes after cardiac arrest (group C, n = 5). Liver function tests, coagulation studies, and liver biopsies were performed during the first 24 hours post-liver transplant. RESULTS: Clamping of the hepatic vasculature in group B produced a significant liver injury compared with the control group: elevation of the ALT and an abnormal 1-hour post-revascularization biopsy similar to that observed in the cardiac arrest group C. The transaminase levels were lower among group A animals (P <.05). But the hepatic synthetic functions as reflected in the protrombin time (PT) were not affected in group B versus group A. The alteration in PT with respect to the initial value was similar among group A and group B animals, which were significantly less than that in group C (P <.05). CONCLUSIONS: Occlusion of the hepatic artery and portal vein, a simple surgical maneuver, causes moderate damage to a liver graft but less alteration of hepatic synthetic function. Clamping of the hepatic vasculture obtains more long-term survivors after OLT than cardiac arrest.
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