Full metadata record
DC Field | Value | Language |
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dc.creator | Martinez-Regueira, F. (Fernando) | - |
dc.creator | Espi, A. (A.) | - |
dc.creator | Nwose, P. (P.) | - |
dc.creator | Diez-Caballero, A. (Alberto) | - |
dc.creator | Baixauli-Fons, J. (Jorge) | - |
dc.creator | Rotellar, F. (Fernando) | - |
dc.creator | Olea, J. (J.) | - |
dc.creator | Pardo, F. (Fernando) | - |
dc.creator | Hernandez-Lizoain, J.L. (Jose Luis) | - |
dc.creator | Álvarez-Cienfuegos, J. (Javier) | - |
dc.date.accessioned | 2012-09-26T11:23:26Z | - |
dc.date.available | 2012-09-26T11:23:26Z | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | Regueira FM, Espí A, Nwose P, Díez-Caballero A, Baixaulí J, Rotellar F, Olea J, Pardo F, Hernández-Lizoain JL, Cienfuegos JA. Comparison between two warm ischemic models in experimental liver transplantation in pigs. Transplant Proc. 2003 Jun;35(4):1591-3. | es_ES |
dc.identifier.issn | 0041-1345 | - |
dc.identifier.uri | https://hdl.handle.net/10171/23229 | - |
dc.description.abstract | Experimental models of warm ischemia in liver transplantation have been employed to study the mechanisms and treatment of ischemia reperfusion injury. METHODS: We compared a control group without (group A, n = 10) versus two models of warm ischemia of liver transplants in pigs: namely, occlusion of the hepatic artery and portal vein for 30 minutes (group B, n = 23) and extraction of the liver 60 minutes after cardiac arrest (group C, n = 5). Liver function tests, coagulation studies, and liver biopsies were performed during the first 24 hours post-liver transplant. RESULTS: Clamping of the hepatic vasculature in group B produced a significant liver injury compared with the control group: elevation of the ALT and an abnormal 1-hour post-revascularization biopsy similar to that observed in the cardiac arrest group C. The transaminase levels were lower among group A animals (P <.05). But the hepatic synthetic functions as reflected in the protrombin time (PT) were not affected in group B versus group A. The alteration in PT with respect to the initial value was similar among group A and group B animals, which were significantly less than that in group C (P <.05). CONCLUSIONS: Occlusion of the hepatic artery and portal vein, a simple surgical maneuver, causes moderate damage to a liver graft but less alteration of hepatic synthetic function. Clamping of the hepatic vasculture obtains more long-term survivors after OLT than cardiac arrest. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Liver/cytology/pathology | es_ES |
dc.subject | Liver Transplantation/physiology | es_ES |
dc.subject | Organ Preservation/methods | es_ES |
dc.title | Comparison Between Two Warm Ischemic Models in Experimental Liver Transplantation in Pigs | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://ac.els-cdn.com/S0041134503004731/1-s2.0-S0041134503004731-main.pdf?_tid=590f73f485322f775cdde35b592f45a3&acdnat=1342092214_ff65a05a2b8fa60fcdb6a2feb8feee03 | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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