Full metadata record
DC Field | Value | Language |
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dc.creator | Camps, J. (J.) | - |
dc.creator | Garcia-Granero, M. (Marta) | - |
dc.creator | Riezu-Boj, J.I. (José Ignacio) | - |
dc.creator | Larrea, E. (Esther) | - |
dc.creator | Alava, E. (Enrique) de | - |
dc.creator | Civeira, M.P. (María Pilar) | - |
dc.creator | Castilla, A. (Alberto) | - |
dc.creator | Prieto, J. (Jesús) | - |
dc.date.accessioned | 2012-09-28T07:24:13Z | - |
dc.date.available | 2012-09-28T07:24:13Z | - |
dc.date.issued | 1994 | - |
dc.identifier.citation | Camps J, Garcia-Granero M, Riezu-Boj JI, Larrea E, de Alava E, Civeira MP, et al. Prediction of sustained remission of chronic hepatitis C after a 12-month course of alfa interferon. J Hepatol 1994 Jul;21(1):4-11. | es_ES |
dc.identifier.issn | 1600-0641 | - |
dc.identifier.uri | https://hdl.handle.net/10171/23249 | - |
dc.description.abstract | alpha-Interferon therapy normalizes aminotransferase levels in approximately 50% of the patients with chronic hepatitis C, but post-therapy relapses are common and predictive factors of sustained response remain largely unknown. We retrospectively assessed several parameters as predictors of sustained remission after a 12-month course of lymphoblastoid alpha-interferon: the Knodell histological activity index, serum levels of procollagen type III peptide, serum HCV-RNA, anti-alpha-interferon antibodies, and anti-HCV antibodies (C-100-3), all at month 12. Thirty-seven patients were studied. Fourteen patients were non-responders (38%), 15 patients experienced a sustained response (40.5%) and eight patients responded similarly but relapsed after alpha-interferon withdrawal (21.5%). A decrease in the histological activity index above 5, normalization of procollagen type III peptide levels (< 12 ng/ml) and the absence of viremia after treatment were all significantly associated with a sustained response (p = 0.008, p = 0.007 and p = 0.037, respectively). Anti-interferon antibodies were detected in only one non-responder patient. Anti-C-100-3 antibodies became undetectable at month 12 in 5 of the 15 sustained responders. The best prediction of sustained response was obtained from the three variables independent of multivariate analysis according to the following equation: F = 0.872 + 0.067 x K (decrease of histological index) -0.052 x P (procollagen type III peptide levels at month 12) -0.28 x R (HCV-RNA at month 12; R = 2 when present and R = 1 when absent). A score higher than 0 predicted sustained remission with a 100% sensitivity and specificity in this series of patients. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Aminotransferases | es_ES |
dc.subject | Anti-HCV antibodies | es_ES |
dc.subject | Anti-interferon antibodies | es_ES |
dc.subject | HCV RNA | es_ES |
dc.subject | Histological activity index | es_ES |
dc.subject | Procollagen III peptide | es_ES |
dc.title | Prediction of sustained remission of chronic hepatitis C after a 12-month course of alfa interferon | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0168827894801290 | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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