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dc.creatorRodriguez-Ortigosa, C.M. (Carlos M.)-
dc.creatorVesperinas, I. (Idoia)-
dc.creatorQian, C. (Cheng)-
dc.creatorQuiroga, J. (Jorge)-
dc.creatorMedina, J.F. (Juan Francisco)-
dc.creatorPrieto, J. (Jesús)-
dc.date.accessioned2012-10-03T12:48:49Z-
dc.date.available2012-10-03T12:48:49Z-
dc.date.issued1995-
dc.identifier.citationRodriguez-Ortigosa CM, Vesperinas I, Qian C, Quiroga J, Medina JF, Prieto J. Taurocholate-stimulated leukotriene C4 biosynthesis and leukotriene C4-stimulated choleresis in isolated rat liver. Gastroenterology 1995 Jun;108(6):1793-1801.es_ES
dc.identifier.issn1528-0012-
dc.identifier.urihttp://hdl.handle.net/10171/23288-
dc.description.abstractBACKGROUND/AIMS: Cysteinyl-containing leukotrienes seem to exert a cholestatic effect. However, leukotriene inhibitors were found to reduce bile salt efflux in isolated rat hepatocytes, suggesting a role for leukotrienes in bile flow formation. METHODS: In the isolated rat liver, the effects of two different concentrations of leukotriene C4 on bile flow and bile salt excretion are analyzed, as well as the possible effect of taurocholate on the hepatic production of cysteinyl-containing leukotrienes. RESULTS: Leukotriene C4 (0.25 fmol) increased bile salt excretion (+22.2%; P < 0.05), whereas a much higher dose (0.25 x 10(6) fmol) showed the known cholestatic effect, reducing bile salt excretion (-25.9%; P < 0.01). These dose-dependent biphasic effects were specific because they could be prevented by the simultaneous administration of cysteinyl-containing leukotriene antagonists. On the other hand, taurocholate administration induced a dose-dependent increase in biliary excretion of cysteinyl-containing leukotrienes. Furthermore, taurocholate increased messenger RNA levels of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis. Taurocholate increase of hepatocyte intracellular calcium was not significant, suggesting that taurocholate effects are not mediated by stimulation of calcium metabolism. CONCLUSIONS: These results constitute evidence for the existence of a positive feedback mechanism by which bile salts stimulate the synthesis of leukotrienes that, in turn, stimulate bile salt excretion.es_ES
dc.language.isoenges_ES
dc.publisherWB Saunderses_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectCholagogues and Choleretics/pharmacologyes_ES
dc.subjectLeukotriene C4/biosynthesises_ES
dc.subjectLiver/drug effectses_ES
dc.subjectTaurocholic Acid/pharmacologyes_ES
dc.titleTaurocholate-stimulated leukotriene C4 biosynthesis and leukotriene C4-stimulated choleresis in isolated rat liveres_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/0016508595901426es_ES
dc.type.driverinfo:eu-repo/semantics/articlees_ES

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