Immunochemotherapy against colon cancer by gene transfer of interleukin-12 in combination with oxaliplatin
Keywords: 
Interleukin-12
Oxaliplatin
Colorectal cancer
Liver
Adenovirus
Issue Date: 
2012
Publisher: 
Landes Bioscience
ISSN: 
2162-402X
Citation: 
Hernandez-Alcoceba R, Berraondo P. Immunochemotherapy against colon cancer by gene transfer of interleukin-12 in combination with oxaliplatin. Oncoimmunology 2012 Jan 1;1(1):97-99.
Abstract
Using a murine model of liver metastases, we found that oxaliplatin can enhance the immunostimulatory effect of interleukin-12 delivered by an adenoviral vector. A shift toward a favorable immune microenvironment was observed in tumors, with a relative increase in CD8+ T cells vs. T regulatory and myeloid-derived suppressor cells.

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