Immunochemotherapy against colon cancer by gene transfer of interleukin-12 in combination with oxaliplatin

Hernandez-Alcoceba, R. (Rubén); Berraondo, P. (Pedro)

Authors:

Hernandez-Alcoceba, R. (Rubén)

Berraondo, P. (Pedro)

Keywords:

Interleukin-12
Oxaliplatin
Colorectal cancer
Liver
Adenovirus

Issue Date:

2012

Publisher:

Landes Bioscience

Publisher Version:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376956/

ISSN:

2162-402X

Citation:

Hernandez-Alcoceba R, Berraondo P. Immunochemotherapy against colon cancer by gene transfer of interleukin-12 in combination with oxaliplatin. Oncoimmunology 2012 Jan 1;1(1):97-99.

Abstract

Using a murine model of liver metastases, we found that oxaliplatin can enhance the immunostimulatory effect of interleukin-12 delivered by an adenoviral vector. A shift toward a favorable immune microenvironment was observed in tumors, with a relative increase in CD8+ T cells vs. T regulatory and myeloid-derived suppressor cells.

URI:

https://hdl.handle.net/10171/23297

Appears in Collections:

DA - CIMA - Terapia génica - Terapia génica del cáncer - Artículos de revista

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