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|Tumor angiogenesis assessed by three-dimensional power Doppler ultrasound in early, advanced and metastatic ovarian cancer: a preliminary study|
|Authors: ||Alcazar, J.L. (Juan Luis)|
|Keywords: ||3D ultrasound|
|Issue Date: ||2006|
|Publisher version: ||http://onlinelibrary.wiley.com/doi/10.1002/uog.3804/pdf|
|Citation: ||Alcazar JL. Tumor angiogenesis assessed by three-dimensional power Doppler ultrasound in early, advanced and metastatic ovarian cancer: A preliminary study. Ultrasound Obstet Gynecol 2006 Sep;28(3):325-329.|
Objective To evaluate tumor vascularity by threedimensional
power Doppler ultrasound (3D-PDU) in
early and advanced stage primary ovarian cancers and
in metastatic tumors to the ovary.
Patients and methods This was a retrospective analysis
of clinical and sonographic data from 49 women
with primary ovarian cancers or metastatic tumors to
the ovary. All women underwent 3D-PDU prior to
surgery. Vascularization index (VI), flow index (FI) and
vascularization flow index (VFI) from solid portions or
papillary projections in the tumors were calculated using
the Virtual Organ Computer-aided AnaLysis (VOCALTM)
program. Definitive histological diagnosis was obtained
in each case.
Results Among the 49 women, 10 had stage I primary
cancers (five low-malignant potential tumors and five
invasive tumors), 26 had advanced stage primary ovarian
cancers and 13 had metastatic tumors to the ovary. Mean
VI and VFI were significantly higher in advanced stage
tumors and metastatic tumors as compared with early
stage tumors. No differences in 3D-PDU indices were
found between advanced stage and metastatic cancers.
Conclusions Vascular indices derived from 3D-PDU tend
to be higher in advanced stage and metastatic ovarian
cancers as compared with early stage ovarian tumors.
|Permanent link: ||http://hdl.handle.net/10171/23339|
|Appears in Collections:||DA - CUN - Ginecología y Obstetricia - Artículos de revista|
|Files in This Item:|
||Ultrasound Obstet Gynecol 2006.325.pdf|
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