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Serum HER-2 concentration is associated with insulin resistance and decreases after weight loss.
Authors: Fernandez-Real, J.M. (José Manuel)
Menendez, J.A. (Javier A.)
Frühbeck, G. (Gema)
Moreno-Navarrete, J. (José)
Vazquez-Martin, A. (Alejandro)
Ricart, W. (Wifredo)
Keywords: Serum HER-2
Insulin resistance
Issue Date: 2010
Publisher: BioMed Central
Publisher version:
ISSN: 1743-7075
Citation: Fernandez-Real JM, Menendez JA, Fruhbeck G, Moreno-Navarrete JM, Vazquez-Martin A, Ricart W. Serum HER-2 concentration is associated with insulin resistance and decreases after weight loss. Nutr Metab (Lond) 2010 Feb 25;7:14.
HER2/neu is a member of the epidermal growth factor receptor family easily detectable in the serum of cancer patients. We aimed to evaluate circulating HER-2 concentrations in association with insulin resistance in healthy and obese subjects. METHODS: Insulin sensitivity (minimal model) and serum HER-2 concentrations were evaluated in a cross sectional study in men (cohort 1, n = 167) and longitudinally after weight loss in obese subjects (cohort 2, n = 30). RESULTS: Serum HER-2 concentrations were positively associated with BMI and waist circumference (both r = 0.18, p = 0.02), post-load glucose (r = 0.28, p = 0.001) and fasting triglycerides (r = 0.26, p = 0.001); and negatively associated with insulin sensitivity (r = -0.29, p = 0.002, n = 109). Subjects with type 2 diabetes showed significantly increased soluble serum HER-2 concentrations. In different multivariate regression models, fasting triglycerides emerged as the factor that independently contributed to 10-11% of serum HER-2 variance.Serum HER-2 concentrations correlated significantly with fasting triglycerides and insulin sensitivity index in subjects from cohort 2. Weight loss led to a significant decrease of serum HER-2 concentrations. The change in serum HER-2 concentrations were significantly associated with the change in percent body fat and fasting triglycerides in young (below the median age of the cohort) subjects. CONCLUSIONS: Serum HER-2 concentrations might be implicated in the pathophysiology of insulin resistance and associated comorbidities.
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DA - CUN - Endocrinología y Nutrición - Artículos de revista

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