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Dadun > Depósito Académico > Clínica Universidad de Navarra > Microbiología clínica > DA - CUN - Microbiología clínica - Artículos de revista >

Promotion of platelet aggregation by sera from brucellosis patients with antiphosphatidylcholine antibodies
Autor(es) : Casao, M.A. (María Ángeles)
Diaz, R. (Ramón)
Orduña, A. (Antonio)
Gamazo, C. (Carlos)
Palabras clave : Antibodies, Bacterial/blood/immunology
Antibody Specificity
Brucellosis/immunology/physiopathology
Fecha incorporación: 2001
Editorial : Society for General Microbiology
Versión del editor: http://jmm.sgmjournals.org/content/50/11/965.long
ISSN: 0022-2615
Cita: Casao MA, Diaz R, Orduna A, Gamazo C. Promotion of platelet aggregation by sera from brucellosis patients with antiphosphatidylcholine antibodies. J Med Microbiol 2001 Nov;50(11):965-968.
Resumen
Results obtained in this study suggest that in human brucellosis there is an antibody response against platelet-activating factor (PAF) and phosphatidylcholine (PC). The specificity of the antiphospholipid response was determined by inhibition assays. The PAF molecule was able to inhibit the anti-PC activity of the brucellosis-control serum. This inhibition capacity of PAF was similar to that of the phosphorylcholine (PYC) group. These results suggest that the inhibition activity could be attributed to the PYC group present in both PAF and PC molecules. Consequently, these findings support an immunodominant role of PYC in the antiphospholipid response of brucellosis. Furthermore, sera from patients infected with Brucella organisms were able to cause platelet aggregation, as were brucella phospholipids, suggesting a possible role of the antiphospholipid antibodies and phospholipids in the inflammatory response in brucellosis.
Enlace permanente: http://hdl.handle.net/10171/23358
Aparece en las colecciones: DA - Medicina - Microbiología y Parasitología - Artículos de revista
DA - CUN - Microbiología clínica - Artículos de revista

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Fichero:  J Med Microbiol 2001. 965.pdf
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