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Dadun > Depósito Académico > Clínica Universidad de Navarra > Endocrinología y Nutrición > DA - CUN - Endocrinología y Nutrición - Artículos de revista >

The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation
Autor(es) : Frühbeck, G. (Gema)
Gomez-Ambrosi, J. (Javier)
Muruzabal, F.J. (Francisco José)
Burrell, M.A. (M.A.)
Palabras clave : Endocrine Glands/physiology
Energy Metabolism/physiology
Insulin Resistance/physiology
Fecha incorporación: 2001
Editorial : American Physiological Society
Versión del editor: http://ajpendo.physiology.org/content/280/6/E827.full.pdf+html
ISSN: 0193-1849
Cita: Fruhbeck G, Gomez-Ambrosi J, Muruzabal FJ, Burrell MA. The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. Am J Physiol Endocrinol Metab 2001 Jun;280(6):E827-47.
Resumen
The ability to ensure continuous availability of energy despite highly variable supplies in the environment is a major determinant of the survival of all species. In higher organisms, including mammals, the capacity to efficiently store excess energy as triglycerides in adipocytes, from which stored energy could be rapidly released for use at other sites, was developed. To orchestrate the processes of energy storage and release, highly integrated systems operating on several physiological levels have evolved. The adipocyte is no longer considered a passive bystander, because fat cells actively secrete many members of the cytokine family, such as leptin, tumor necrosis factor-alpha, and interleukin-6, among other cytokine signals, which influence peripheral fuel storage, mobilization, and combustion, as well as energy homeostasis. The existence of a network of adipose tissue signaling pathways, arranged in a hierarchical fashion, constitutes a metabolic repertoire that enables the organism to adapt to a wide range of different metabolic challenges, such as starvation, stress, infection, and short periods of gross energy excess.
Enlace permanente: http://hdl.handle.net/10171/23359
Aparece en las colecciones: DA - Medicina - Endocrinología - Artículos de revista
DA - Ciencias - HAP - Artículos de revista
DA - CUN - Endocrinología y Nutrición - Artículos de revista

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Fichero:  Am J Physiol Endocrinol Metab 2001. E827.pdf
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