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Neurohormonas y citocinas en la insuficiencia cardíaca. Correlación con la reserva de flujo coronario
Otros títulos : Coma-Canella I, Macias A, Varo N, Sanchez Ibarrola A. Neurohormonas y citocinas en la insuficiencia cardíaca. Correlación con la reserva de flujo coronario. Rev Esp Cardiol 2005 Nov;58(11):1273-1277.
Autor(es) : Coma-Canella, I. (Isabel)
Macias, A. (Alfonso)
Varo, N. (Nerea)
Sanchez-Ibarrola, A. (Alfonso)
Palabras clave : Heart failure
Coronary flow reserve
Cytokines
Fecha incorporación: 2005
Editorial : Elsevier España
Versión del editor: http://apps.elsevier.es/watermark/ctl_servlet?_f=10&pident_articulo=13080955&pident_usuario=0&pcontactid=&pident_revista=25&ty=139&accion=L&origen=elsevier&web=www.revespcardiol.org&lan=es&fichero=25v55n11a13080955pdf001.pdf
ISSN: 0300-8932
Resumen
Introduction and objectives. In heart failure, the coronary flow reserve (CFR) measured by positron-emission tomography (PET) is reduced. As neurohormone and cytokine levels are also altered in patients with the condition, our aim was to determine whether there is a correlation between CFR and neurohormone and cytokine levels. Patients and method. The study included 40 patients with heart failure but without ischemic heart disease. Myocardial blood flow was measured by PET using nitrogen- 13 ammonia at baseline and during ATP infusion. The CFR was calculated for each patient. In addition, levels of the following were determined: norepinephrine, endothelin- 1, angiotensin-II, atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), tumor necrosis factor-alpha, interleukin (IL)-1β, soluble IL-2 receptor, and IL-6. Results. All neurohormone levels were elevated above reference values. The levels of all cytokines, except IL-1β, were also elevated. There was a significant negative correlation between CFR and the levels of several neurohormones: ANP (r=–0.476), BNP (r=–0.442), and IL-6 (r=–0.509). Conclusions. In heart failure, the decrease in CFR is correlated with increases in the levels of certain neurohormones (i.e., ANP and BNP) and cytokines (i.e., IL-6), with vasodilatory effect. These increases are probably are related to compensatory mechanisms that are unable to correct for the endothelial dysfunction present in these patients.
Enlace permanente: http://hdl.handle.net/10171/23496
Aparece en las colecciones: DA - CUN - Inmunología - Artículos de revista
DA - CUN - Bioquímica clínica - Artículos de revista
DA - CUN - Cardiología - Artículos de revista

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Fichero:  Rev Esp Cardiol 2005. 1273.pdf
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