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Herpes Zoster After Liver Transplantation: Incidence, Risk Factors, and Complications
Authors: Herrero, J.I. (José Ignacio)
Quiroga, J. (Jorge)
Sangro, B. (Bruno)
Pardo, F. (Fernando)
Rotellar, F. (Fernando)
Cienfuegos, J.A. (Javier A.)
Prieto, J. (Jesús)
Keywords: Herpes Zoster/epidemiology/immunology
Herpesvirus 3, Human/physiology
Liver Cirrhosis/surgery/virology
Issue Date: 2004
Publisher: Wiley-Blackwell
Publisher version:
ISSN: 1527-6465
Citation: Herrero JI, Quiroga J, Sangro B, Pardo F, Rotellar F, Alvarez-Cienfuegos J, et al. Herpes zoster after liver transplantation: incidence, risk factors, and complications. Liver Transpl 2004 Sep;10(9):1140-1143.
Herpes zoster is the consequence of the reactivation of latent varicella-zoster infection. Immunosuppression may be a predisposing factor for herpes zoster. We have retrospectively assessed the risk of herpes zoster, the risk factors for its occurrence, and its evolution in a population of 209 consecutive liver transplant recipients. Herpes zoster developed in 25 (12%) of patients. One-, 3-, 5-, and 10-year actuarial rates of herpes zoster were 3%, 10%, 14%, and 18%, respectively. In a case-control study, patients developing herpes zoster were younger, received a higher number of immunosuppressive drugs, and were more frequently receiving mycophenolate mofetil or azathioprine. In multivariate analysis, the only factor related to herpes zoster occurrence was treatment with mycophenolate mofetil or azathioprine. Eight patients (31%) developed postherpetic neuralgia. In conclusion, herpes zoster is a relatively common complication after liver transplantation. It is related to immunosuppressive therapy. Postherpetic neuralgia develops in one third of patients with posttransplant herpes zoster.
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Appears in Collections:DA - CUN - Cirugía general y digestiva - Artículos de revista
DA - CUN - Hepatología - Artículos de revista
DA - CUN - Medicina interna - Artículos de revista

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