Vicente E, Charnaud S, Bongard E, Villar R, Burguete A, Solano B, et al. Synthesis and antiplasmodial activity of 3-furyl and 3-thienylquinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives. Molecules 2008 Jan 17;13(1):69-77.
The aim of this study was to identify new compounds active against
Plasmodium falciparum based on our previous research carried out on 3-phenylquinoxaline-
2-carbonitrile 1,4-di-N-oxide derivatives. Twelve compounds were
synthesized and evaluated for antimalarial activity. Eight of them showed an IC50 < 1 μM
against the 3D7 strain. Derivative 1 demonstrated high potency (IC50= 0.63 μM) and good
selectivity (SI=10.35), thereby becoming a new lead-compound.