Barea C, Pabon A, Galiano S, Perez-Silanes S, Gonzalez G, Deyssard C, et al. Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives. Molecules 2012 Aug 7;17(8):9451-9461.
Malaria and leishmaniasis are two of the World’s most important tropical
parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline
1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their in vitro
antimalarial and antileishmanial activity against erythrocytic forms of Plasmodium
falciparum and axenic forms of Leishmania infantum. Their toxicity against VERO cells
(normal monkey kidney cells) was also assessed. None of the tested compounds was
efficient against Plasmodium, but two of them showed good activity against Leishmania.
Toxicity on VERO was correlated with leishmanicidal properties.