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DC FieldValueLanguage
dc.creatorBarea, C. (Carlos)-
dc.creatorPabon, A. (Adriana)-
dc.creatorGaliano, S. (Silvia)-
dc.creatorPérez-Silanes, S. (Silvia)-
dc.creatorGonzalez, G. (Germán)-
dc.creatorDeyssard, C. (Chloe)-
dc.creatorMonge, A. (Antonio)-
dc.creatorDeharo, E. (Eric)-
dc.creatorAldana, I. (Ignacio)-
dc.date.accessioned2012-10-31T17:42:13Z-
dc.date.available2012-10-31T17:42:13Z-
dc.date.issued2012-
dc.identifier.citationBarea C, Pabon A, Galiano S, Perez-Silanes S, Gonzalez G, Deyssard C, et al. Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives. Molecules 2012 Aug 7;17(8):9451-9461.es_ES
dc.identifier.issn1420-3049-
dc.identifier.urihttp://hdl.handle.net/10171/23601-
dc.description.abstractMalaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against erythrocytic forms of Plasmodium falciparum and axenic forms of Leishmania infantum. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. None of the tested compounds was efficient against Plasmodium, but two of them showed good activity against Leishmania. Toxicity on VERO was correlated with leishmanicidal properties.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectQuinxalinees_ES
dc.subjectPiperazinees_ES
dc.subjectPlasmodiumes_ES
dc.subjectLeishmaniaes_ES
dc.subjectVEROes_ES
dc.titleAntiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives.es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://www.mdpi.com/journal/moleculeses_ES
dc.type.driverinfo:eu-repo/semantics/articlees_ES

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