Molecular features in a biphenotypic small cell sarcoma with neuroectodermal and muscle differentiation
Palabras clave : 
Muscle Neoplasms/genetics/immunology/pathology
Sarcoma, Small Cell/genetics/immunology/pathology
Tumor Markers, Biological/analysis
Fecha de publicación: 
1998
Editorial : 
WB Saunders
ISSN: 
0046-8177,
Cita: 
de Alava E, Lozano MD, Sola I, Panizo A, Idoate MA, Martinez-Isla C, et al. Molecular features in a biphenotypic small cell sarcoma with neuroectodermal and muscle differentiation. Hum Pathol 1998 Feb;29(2):181-184.
Resumen
We report a case of a 13-year-old girl with soft tissue sarcoma of the hand, which showed muscle and neuroectodermal immunophenotypes. Molecular studies were performed on RNA collected from fine-needle aspiration (FNA) cytology and peripheral blood samples by nested reverse transcriptase-polymerase chain reaction (RT-PCR) and Southern blot analysis. This biphenotypic tumor showed simultaneous expression of EWS-FLI1 and PAX3-FKHR transcripts, specific of Ewing family tumors and alveolar rhabdomyosarcoma, respectively. Although childhood sarcomas with simultaneous muscle and neural differentiation have been described to have EWS-FLI1 transcripts, there are no reports of tumors with both transcripts. Cytological specimens are a good source of RNA for molecular studies

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Fichero: 
Hum Pathol.1998.181.pdf
Descripción: 
Tamaño: 
253,25 kB
Formato: 
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