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Pediatric Meningosarcoma: Clinical Evolution and Genetic Instability
Authors: Lopez-de-la-Mesa, R. (R.)
Sierrasesumaga, L. (Luis)
Lopez-de-Cerain, A. (Adela)
Calasanz-Abinzano, M.J. (Maria Jose)
Patiño, A. (Ana)
Keywords: Magnetic Resonance Imaging
Tumor Suppressor Protein p53/genetics
Meningeal Neoplasms/genetics/pathology
Issue Date: 2005
Publisher: Elsevier
Publisher version:
ISSN: 0887-8994
Citation: de Mesa RL, Sierrasesúmaga L, de Cerain AL, Calasanz MJ, Patiño-García A. Pediatric meningosarcoma: clinical evolution and genetic instability. Pediatr Neurol. 2005 May;32(5):352-4.
This report presents a female diagnosed with a frontoparietal interhemispheric meningosarcoma who, parallel to the clinical worsening, revealed an increase in the genetic instability (in bleomycin cultures) and the complexity of the karyotypes, with the acquisition of a clonal deletion of 17p13 (the locus for the TP53 tumor suppressor gene). The genetic findings of this patient suggest that the increased genetic instability could contribute to tumor progression as well as to treatment resistance, possibly in the background of the clonal deletion of TP53.
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