Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Sanchez-Carpintero, R. (Rocío) | - |
dc.creator | Narbona, J. (Juan) | - |
dc.creator | Lopez-de-la-Mesa, R. (R.) | - |
dc.creator | Arbizu, J. (Javier) | - |
dc.creator | Sierrasesumaga, L. (Luis) | - |
dc.date.accessioned | 2012-11-22T16:36:28Z | - |
dc.date.available | 2012-11-22T16:36:28Z | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Sánchez-Carpintero R, Narbona J, López de Mesa R, Arbizu J, Sierrasesúmaga L. Transient posterior encephalopathy induced by chemotherapy in children. Pediatr Neurol. 2001 Feb;24(2):145-8. | es_ES |
dc.identifier.issn | 0887-8994 | - |
dc.identifier.uri | https://hdl.handle.net/10171/23778 | - |
dc.description.abstract | The cases of three children, 16, 12, and 12 years of age, who suffered sudden confusional state and cortical blindness lasting 12 to 30 minutes while under treatment with high-dose methotrexate, cyclophosphamide, and dactinomycin for a lower limb osteosarcoma are reported. Transient neuropsychologic deficits arose after the acute phase of treatment: left hemispatial neglect and constructive apraxia (Patient 1); constructive apraxia (Patient 2); and constructive apraxia and alexia without aphasia (Patient 3). The three patients recovered completely from all their deficits within the time frame of 3 hours to 2 weeks. Arterial hypertension and hypomagnesemia were found during the acute phase in all patients. In Patients 2 and 3, magnetic resonance imaging revealed increased parieto-occipital T(2) signal involving gray and white matter. In Patients 1 and 2, HmPAO-SPECT revealed parieto-occipital hypoperfusion that resolved a few days later. The alterations detected by neuroimaging were concurrent with the appearance and disappearance of the clinical symptoms. Such transient acute episodes have been named occipital-parietal encephalopathy. On the basis of our clinical, laboratory, and neuroimaging findings, an explanation for the origin of this syndrome, a migrainelike mechanism, triggered by chemotherapy-induced hypomagnesemia, is proposed. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Hypertension/chemically induced | es_ES |
dc.subject | Magnesium Deficiency/chemically induced | es_ES |
dc.subject | Osteosarcoma/drug therapy | es_ES |
dc.title | Transient Posterior Encephalopathy Induced by Chemotherapy in Children | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1016/S0887-8994(00)00242-3 | es_ES |
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