Scoliosis induced by medullary damage: an experimental study in rabbits
Palabras clave : 
Disease Models, Animal
Fecha de publicación: 
Editorial : 
Lippincott, Williams & Wilkins
Barrios C, Tuñon MT, De Salis JA, Beguiristain JL, Cañadell JM. Scoliosis Induced by Medullary Damage: An Experimental Study in Rabbits. Spine (Phila Pa 1976). 1987 Jun;12(5):433-9.
To date, there have been no reports of experiments designed to induce scoliosis by direct damage of different areas of the spinal cord. In a series of rabbits with medullary damage, the authors attempted selectively to interrupt the pathways that mediate proprioceptive input. Unilateral lesion of the dorsal column and posterior horn of the spinal cord was performed using three different techniques: coagulation with laser, stereotaxic microcoagulation, and longitudinal electrocoagulation. Of 32 operated rabbits, 17 developed scoliosis, exhibiting clear pathologic damage of the spinal cord. Electrophysiologic study, including EMG and analysis of the tonic -- vibratory reflex, was performed on 10 rabbits with medullary damage (scoliotic and non-scoliotic) and 12 matched controls. The data suggest disturbance of the sensory afferences that control the postural tone and consequent muscular imbalance, expressed as reduced activity in the muscles of the convex side. This work supports the view that loss of proprioceptive neural impulses caused by medullary damage can induce scoliosis

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