Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Sanchez-Carpintero-Abad, I. (Ignacio) | - |
dc.creator | España, A. (Agustín) | - |
dc.creator | Pelacho, B. (Beatriz) | - |
dc.creator | Lopez-Moratalla, N. (Natalia) | - |
dc.creator | Rubenstein, D.S. (D. S.) | - |
dc.creator | Diaz, L.A. (L. A.) | - |
dc.creator | Lopez-Zabalza, M.J. (María Jesús) | - |
dc.date.accessioned | 2012-12-04T09:48:56Z | - |
dc.date.available | 2012-12-04T09:48:56Z | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Sanchez-Carpintero I, Espana A, Pelacho B, Lopez Moratalla N, Rubenstein DS, Diaz LA, et al. In vivo blockade of pemphigus vulgaris acantholysis by inhibition of intracellular signal transduction cascades. Br J Dermatol 2004 Sep;151(3):565-570. | es_ES |
dc.identifier.issn | 0007-0963 | - |
dc.identifier.uri | https://hdl.handle.net/10171/27343 | - |
dc.description.abstract | Pemphigus vulgaris (PV) is an autoimmune disease characterized by mucocutaneous intraepithelial blisters and pathogenic autoantibodies against desmoglein 3. The mechanism of blister formation in pemphigus has not been defined; however, in vitro data suggest a role for activation of intracellular signalling cascades. OBJECTIVES: To investigate the contribution of these signalling pathways to the mechanism of PV IgG-induced acantholysis in vivo. METHODS: We used the passive transfer mouse model. Mice were injected with IgG fractions of sera from a patient with PV, with or without pretreatment with inhibitors of proteins that mediate intracellular signalling cascades. RESULTS: Inhibitors of tyrosine kinases, phospholipase C, calmodulin and the serine/threonine kinase protein kinase C prevented PV IgG-induced acantholysis in vivo. CONCLUSIONS: These observations strongly support the role of intracellular signalling cascades in the molecular mechanism of PV IgG-induced acantholysis | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley-Blackwell | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Calmodulin/antagonists & inhibitors/physiology | es_ES |
dc.subject | Immunoglobulin G/immunology | es_ES |
dc.subject | Protein Kinases/physiology | es_ES |
dc.title | Cutaneous Biology: In vivo blockade of pemphigus vulgaris acantholysis by inhibition of intracellular signal transduction cascades | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2133.2004.06147.x/pdf | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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