Lesions of pemphigus vulgaris on irradiated skin
Keywords: 
Pemphigus/etiology/immunology
Radiation Injuries/etiology/immunology
Radiotherapy/adverse effects
Issue Date: 
2009
Publisher: 
Wiley-Blackwell
ISSN: 
0307-6938
Citation: 
Aguado L, Marquina M, Pretel M, Ruiz-Carrillo G, España A. Lesions of pemphigus vulgaris on irradiated skin. Clin Exp Dermatol. 2009 Jul;34(5):e148-50.
Abstract
Summary Pemphigus vulgaris (PV) is an autoimmune blistering disease produced by IgG autoantibodies against desmoglein (Dsg)3. Lesions on the skin and mucosa can, in rare cases, be induced by radiotherapy. We report a patient with a history of microprolactinoma and PV, who had only oral lesions from the beginning of her illness but 2 months after treatment with radiotherapy for a breast neoplasia, developed skin lesions limited to the irradiated area. Over the following few months, she also developed autoantibodies against Dsg1

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