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dc.creatorAnsorena-Artieda, E. (Eduardo)-
dc.creatorRuiz Garcia-Trevijano, E. (Elena)-
dc.creatorMartinez-Chantar, M.L. (María Luz)-
dc.creatorHuang, Z.Z. (Zong-Zhi)-
dc.creatorChen, L. (Lixin)-
dc.creatorMato, J.M. (José María)-
dc.creatorIraburu-Elizalde, M. (María)-
dc.creatorLu, S.C. (Shelly C.)-
dc.creatorAvila, M.A. (Matías Antonio)-
dc.date.accessioned2012-12-19T16:57:29Z-
dc.date.available2012-12-19T16:57:29Z-
dc.date.issued2002-
dc.identifier.citationAnsorena E, Garcia-Trevijano ER, Martinez-Chantar ML, Huang ZZ, Chen L, Mato JM, et al. S-adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cells. Hepatology 2002 Feb;35(2):274-280.es_ES
dc.identifier.issn1527-3350-
dc.identifier.urihttps://hdl.handle.net/10171/27495-
dc.description.abstractS-adenosylmethionine (AdoMet) is an essential compound in cellular transmethylation reactions and a precursor of polyamine and glutathione synthesis in the liver. In liver injury, the synthesis of AdoMet is impaired and its availability limited. AdoMet administration attenuates experimental liver damage, improves survival of alcoholic patients with cirrhosis, and prevents experimental hepatocarcinogenesis. Apoptosis contributes to different liver injuries, many of which are protected by AdoMet. The mechanism of AdoMet's hepatoprotective and chemopreventive effects are largely unknown. The effect of AdoMet on okadaic acid (OA)-induced apoptosis was evaluated using primary cultures of rat hepatocytes and human hepatoma cell lines. AdoMet protected rat hepatocytes from OA-induced apoptosis dose dependently. It attenuated mitochondrial cytochrome c release, caspase 3 activation, and poly(ADP-ribose) polymerase cleavage. These effects were independent from AdoMet-dependent glutathione synthesis, and mimicked by 5'-methylthioadenosine (MTA), which is derived from AdoMet. Interestingly, AdoMet and MTA did not protect HuH7 cells from OA-induced apoptosis; conversely both compounds behaved as proapoptotic agents. AdoMet's proapoptotic effect was dose dependent and observed also in HepG2 cells. In conclusion, AdoMet exerts opposing effects on apoptosis in normal versus transformed hepatocytes that could be mediated through its conversion to MTA. These effects may participate in the hepatoprotective and chemopreventive properties of this safe and well-tolerated drug.es_ES
dc.language.isoenges_ES
dc.publisherWiley-Blackwelles_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectApoptosis/drug effectses_ES
dc.subjectCarcinoma, Hepatocellular/physiopathologyes_ES
dc.subjectDeoxyadenosines/pharmacologyes_ES
dc.subjectHepatocytes/drug effectses_ES
dc.subjectHepatocytes/physiologyes_ES
dc.subjectLiver Neoplasms/physiopathologyes_ES
dc.subjectRats/physiologyes_ES
dc.subjectS-Adenosylmethionine/pharmacologyes_ES
dc.subjectThionucleosides/pharmacologyes_ES
dc.titleS-adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cellses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://bit.ly/RMHBEdes_ES
dc.type.driverinfo:eu-repo/semantics/articlees_ES

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