Microchimerism in Graves’ Disease
Keywords: 
Thyroid
Graves’ Disease
Issue Date: 
2012
Publisher: 
SAGE-Hindawi Access to Research
ISSN: 
2042-0072
Citation: 
Galofre JC. Microchimerism in graves' disease. J Thyroid Res 2012;2012:724382.
Abstract
Microchimerism is the presence of cells from one individual in another genetically distinct individual. Pregnancy is the main cause of natural microchimerism through transplacental bidirectional cell trafficking between mother and fetus. The consequences of pregnancy-related microchimerism are under active investigation. However, many authors have suggested a close relationship linking fetal microchimerism and the development of autoimmune diseases. It has been more than ten years now since the demonstration of the presence of a significant high number of fetal microchimeric cells residing in thyroid glands from operated patients with Graves' disease. This intrathyroidal fetal microchimerism is an attractive candidate mechanism for the modulation of Graves' disease in pregnancy and the postpartum period.

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