Farmacología de antimicrobianos utilizados en el tratamiento de las infecciones graves por bacterias grampositivas
Keywords: 
Anti-Bacterial Agents/blood/pharmacology/therapeutic use
Dose-Response Relationship, Drug
Gram-Positive Bacterial Infections/drug therapy
Issue Date: 
2003
Publisher: 
Sociedad Española de Quimioterapia
ISSN: 
0214-3429
Citation: 
Garcia Quetglas E, Azanza Perea JR, Sadaba Diaz de Rada B, Gil Aldea I. Farmacología de antimicrobianos utilizados en el tratamiento de las infecciones graves por bacterias grampositivas. Rev Esp Quimioter 2003 Sep;16(3):277-288.
Abstract
Antimicrobials with specific activity against Gram-positive cocci (glycopeptides, oxazolidinones and streptogramins) have pharmacokinetic differences that are important to know. Linezolid and teicoplanin can be administered extravascularly due to their good bioavailability, allowing their use as sequential therapy in patients requiring prolonged treatment. All of these antimicrobials have an adequate distribution in extracellular tissues, even teicoplanin, due to the balance between the fraction that is bound and unbound to plasma proteins and its long terminal half-life. As the elimination of glycopeptides is almost exclusively renal, it is necessary to perform a posology adjustment in patients with renal failure. Quinupristin/dalfopristin and linezolid are metabolized by the liver, but CYP450 is only involved in streptogramin elimination

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