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DC FieldValueLanguage
dc.creatorGarcia-Quetglas, E. (Emilio)-
dc.creatorAzanza, J.R. (José Ramón)-
dc.creatorSadaba, B. (Belén)-
dc.creatorGil-Aldea, I. (I.)-
dc.date.accessioned2013-01-02T09:17:31Z-
dc.date.available2013-01-02T09:17:31Z-
dc.date.issued2003-
dc.identifier.citationGarcia Quetglas E, Azanza Perea JR, Sadaba Diaz de Rada B, Gil Aldea I. Farmacología de antimicrobianos utilizados en el tratamiento de las infecciones graves por bacterias grampositivas. Rev Esp Quimioter 2003 Sep;16(3):277-288.es_ES
dc.identifier.issn0214-3429-
dc.identifier.urihttp://hdl.handle.net/10171/27543-
dc.description.abstractAntimicrobials with specific activity against Gram-positive cocci (glycopeptides, oxazolidinones and streptogramins) have pharmacokinetic differences that are important to know. Linezolid and teicoplanin can be administered extravascularly due to their good bioavailability, allowing their use as sequential therapy in patients requiring prolonged treatment. All of these antimicrobials have an adequate distribution in extracellular tissues, even teicoplanin, due to the balance between the fraction that is bound and unbound to plasma proteins and its long terminal half-life. As the elimination of glycopeptides is almost exclusively renal, it is necessary to perform a posology adjustment in patients with renal failure. Quinupristin/dalfopristin and linezolid are metabolized by the liver, but CYP450 is only involved in streptogramin eliminationes_ES
dc.language.isospaes_ES
dc.publisherSociedad Española de Quimioterapiaes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectAnti-Bacterial Agents/blood/pharmacology/therapeutic usees_ES
dc.subjectDose-Response Relationship, Druges_ES
dc.subjectGram-Positive Bacterial Infections/drug therapyes_ES
dc.titleFarmacología de antimicrobianos utilizados en el tratamiento de las infecciones graves por bacterias grampositivases_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://www.seq.es/seq/0214-3429/16/3/277.pdfes_ES
dc.type.driverinfo:eu-repo/semantics/articlees_ES

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