Gomez-Caro LC, Sanchez-Sanchez M, Bocanegra-Garcia V, Rivera G. Synthesis of Quinoxaline 1,4-Di-N-Oxide Derivatives on Solid Support using Room Temperature and Microwave-Assisted Solvent-Free Procedures. Quim Nova 2011;34(7):1147-1151
We describe the synthesis of 12 new ethyl and methyl quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives on solid supports with room temperature and microwave-assisted solvent-free procedures. Results show that solid supports have good catalytic activity in the formation of quinoxaline 1,4-di-N-oxide derivatives. We found that florisil and montmorillonite KSF and K10 could be used as new, easily available, inexpensive alternatives of catalysts. Additionally, room temperature and microwave-irradiation solvent-free synthesis was more efficient than a conventional procedure (Beirut reaction), reducing reaction time and increasing yield.