HIV Seropositivity/complications Indomethacin/adverse effects Skin Diseases/pathology
Fecha de publicación:
Allegue F, Boixeda P, España A, Moreno R, Ledo A. Síndrome de Reiter exacerbado por indometacina. Med Cutan Ibero Lat Am. 1989;17(2):113-6.
A 26-year-old man, with a personal history of drug abuse and positive serology for HIV, had Reiter's syndrome for six years. He experienced progressive worsening of his cutaneous lesions after initiation of indomethacin therapy. The skin lesions were almost completely resolved after the discontinuance of the drug and its reintroduction resulted in a similar deterioration. To our knowledge, indomethacin has not been reported to aggravate Reiter's syndrome. This case study documents anti-inflammatory drugs as possible causal factors for triggering Reiter's syndrome. Possible implicated mechanisms are also discussed.