Antiplasmodial activity of 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives
Other Titles: 
Atividade antimalárica de derivados di-N-óxido de 3-trifluorometil-2-carbonilquinoxalina
Keywords: 
Quinoxaline
Antimalarial
Chloroquine
MCF7
Issue Date: 
2006
Publisher: 
Universidade de São Paulo
ISBN: 
1516-9332
Citation: 
Zarranz B, Jaso A, Lima LM, Aldana I, Monge A, Maurel S, et al . Antiplasmodial activity of 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives. Rev Bras Cienc Farm, 2006 Sep;42(3):357-361
Abstract
The in vitro antiplasmodial activity of some 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives is reported. The evaluation was performed on cultures of FcB1 strain (chloroquine-resistant) of P. falciparum and the most interesting compounds were then evaluated on MCF7 tumor cells in order to evaluate an index of selectivity. The 7-methyl (2b, 4b, 5b, 6b) and nonsubstituted (3c, 4c, 5c) quinoxaline 1,4-dioxide derivatives presented the best level of activity.

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