Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Barea, C. (Carlos) | - |
dc.creator | Pabon, A. (Adriana) | - |
dc.creator | Pérez-Silanes, S. (Silvia) | - |
dc.creator | Galiano, S. (Silvia) | - |
dc.creator | Gonzalez, G. (Germán) | - |
dc.creator | Monge, A. (Antonio) | - |
dc.creator | Deharo, E. (Eric) | - |
dc.creator | Aldana, I. (Ignacio) | - |
dc.date.accessioned | 2013-07-18T07:54:43Z | - |
dc.date.available | 2013-07-18T07:54:43Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Barea C, Pabon A, Perez-Silanes S, Galiano S, Gonzalez G, Monge A, et al. New Amide Derivatives of Quinoxaline 1,4-di-N-oxide with Leishmanicidal and antiplasmodial activities. Molecules 2013 Apr;18(4):4718-4727 | es_ES |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://hdl.handle.net/10171/29506 | - |
dc.description.abstract | Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Continuing with our efforts to identify new compounds active against malaria and leishmaniasis, twelve new 1,4-di-N-oxide quinoxaline derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against Plasmodium falciparum FCR-3 strain, Leishmania infantum and Leishmania amazonensis. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. The results obtained indicate that a cyclopentyl derivative had the best antiplasmodial activity (2.9 µM), while a cyclohexyl derivative (2.5 µM) showed the best activity against L. amazonensis, and a 3-chloropropyl derivative (0.7 µM) showed the best results against L. infantum. All these compounds also have a Cl substituent in the R7 position. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Quinoxaline | es_ES |
dc.subject | 1,4-di-N-oxide | es_ES |
dc.subject | Leishmanicidal | es_ES |
dc.subject | Antiplasmodial | es_ES |
dc.title | New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.3390/molecules18044718 | es_ES |
Files in This Item:
Statistics and impact
Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.