Obesity Energy metabolism Weight reduction Neuropeptide Y
Sociedade Brasileira de Química
Aldana I, Rivero I, Rivero A, Huenchunir P, Frigola C, Alonso M, et al. New antagonist agents of neuropeptide Y receptors. Quim Nova 2000 NOV-DEC;23(6):737-741
In the CNS, NPY has been implicated in obesity and feeding, endocrine function and metabolism. Potent and selective rNPY antagonists mill be able to probe the merits of this approach for the treatment of obesity. We report the synthesis and preliminary evaluation of some hydrazide derivatives as antagonists of rNPY.