Design, synthesis and study of quinoxaline-2- carboxamide 1,4-DI-N-Oxide derivatives as anti-tuberculosis agents

Abstract

The experimental work presented in this memory is based on the hypothesis that quinoxalines di-N-oxide, considered to be the core of the structure, which present a carboxamide moiety on position two and aliphatic linker between this group and an aromatic system, can be proposed as potent anti-tuberculosis agents. The main purpose of this project is the synthesis of new quinoxaline di-N-oxide derivatives as anti-tuberculosis agents. The strategy consists of the design and synthesis of several derivatives of each series, and their in vitro biological evaluation against M.tb. Some compounds will be selected, based on their structural variability and biological results, for an in depth study of the physicochemical properties and electrochemical behavior of this family of derivatives. A series of specific objectives are proposed in order to achieve the main purpose of this project: 1. Bibliographic review: state of the art. 2. Design of new quinoxaline di-N-oxide derivatives. 3. Synthesis of the designed compounds. 4. Characterization of the synthesized compounds. 5. In vitro biological evaluation of the synthesized derivatives. 6. Study of the lipophilicity of quinoxaline di-N-oxide derivatives. 7. Study of the electrochemical behavior of quinoxaline di-N-oxide derivatives. 8. Study of possible structure-property and structure-activity relationships (SPR, SAR). 9. Search of new lead compounds and design of future work plans.