Identification of tissue microRNAs predictive of sunitinib activity in patients with metastatic renal cell carcinoma
Keywords: 
Tissue microRNAs
Metastatic renal
Carcinoma
Issue Date: 
2014
Publisher: 
Public Library of Science
ISSN: 
1932-6203
Citation: 
Prior C, Pérez-Gracia JL, García-Donas J, Rodríguez-Antona C, Guruceaga E, Esteban E, et al. Identification of tissue microRNAs predictive of sunitinib activity in patients with metastatic renal cell carcinoma. PLoS One. 2014 Jan 24;9(1):e86263
Abstract
We identified differentially expressed microRNAs in MRCC patients presenting marked sensitivity or resistance to sunitinib. MiR-942 was the best predictor of efficacy. We describe a novel paracrine mechanism through which high miR-942 levels in MRCC cells up-regulates MMP-9 and VEGF secretion to enhance endothelial migration and sunitinib resistance. Our results support further validation of these miRNA in clinical confirmatory studies.

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