Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Prior, C. (Celia) | - |
dc.creator | Perez-Gracia, J.L. (Jose Luis) | - |
dc.creator | Garcia-Donas, J. (Jesús) | - |
dc.creator | Rodriguez-Antona, C. (Cristina) | - |
dc.creator | Guruceaga, E. (Elizabeth) | - |
dc.creator | Esteban-Gutiérrez, E. (Emilio) | - |
dc.creator | Suárez, C. (Cristina) | - |
dc.creator | Castellano, D. (Daniel) | - |
dc.creator | Gonzalez-del-Alba, A. (Aránzazu) | - |
dc.creator | Lozano, M.D. (María Dolores) | - |
dc.creator | Carles, J. (Joan) | - |
dc.creator | Climent, M.A. (Miguel Ángel) | - |
dc.creator | Arranz, J.A. (Jose Ángel) | - |
dc.creator | Gallardo, E. (Enrique) | - |
dc.creator | Puente, J. (Javier) | - |
dc.creator | Bellmunt, J. (Joaquim) | - |
dc.creator | Gurpide, A. (Alfonso) | - |
dc.creator | Lopez-Picazo, J.M. (José M.) | - |
dc.creator | Gonzalez-Hernandez, A. (Alvaro) | - |
dc.creator | Mellado, B. (Begoña) | - |
dc.creator | Martinez, E. (Esther) | - |
dc.creator | Moreno, F. (Fernando) | - |
dc.creator | Font, A. (Albert) | - |
dc.creator | Calvo-González, A. (Alfonso) | - |
dc.date.accessioned | 2014-02-27T08:23:44Z | - |
dc.date.available | 2014-02-27T08:23:44Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Prior C, Pérez-Gracia JL, García-Donas J, Rodríguez-Antona C, Guruceaga E, Esteban E, et al. Identification of tissue microRNAs predictive of sunitinib activity in patients with metastatic renal cell carcinoma. PLoS One. 2014 Jan 24;9(1):e86263 | es_ES |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://hdl.handle.net/10171/35300 | - |
dc.description.abstract | We identified differentially expressed microRNAs in MRCC patients presenting marked sensitivity or resistance to sunitinib. MiR-942 was the best predictor of efficacy. We describe a novel paracrine mechanism through which high miR-942 levels in MRCC cells up-regulates MMP-9 and VEGF secretion to enhance endothelial migration and sunitinib resistance. Our results support further validation of these miRNA in clinical confirmatory studies. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Public Library of Science | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Tissue microRNAs | es_ES |
dc.subject | Metastatic renal | es_ES |
dc.subject | Carcinoma | es_ES |
dc.title | Identification of tissue microRNAs predictive of sunitinib activity in patients with metastatic renal cell carcinoma | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
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