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dc.creatorPrior, C. (Celia)-
dc.creatorPerez-Gracia, J.L. (Jose Luis)-
dc.creatorGarcia-Donas, J. (Jesús)-
dc.creatorRodriguez-Antona, C. (Cristina)-
dc.creatorGuruceaga, E. (Elizabeth)-
dc.creatorEsteban-Gutiérrez, E. (Emilio)-
dc.creatorSuárez, C. (Cristina)-
dc.creatorCastellano, D. (Daniel)-
dc.creatorGonzalez-del-Alba, A. (Aránzazu)-
dc.creatorLozano, M.D. (María Dolores)-
dc.creatorCarles, J. (Joan)-
dc.creatorCliment, M.A. (Miguel Ángel)-
dc.creatorArranz, J.A. (Jose Ángel)-
dc.creatorGallardo, E. (Enrique)-
dc.creatorPuente, J. (Javier)-
dc.creatorBellmunt, J. (Joaquim)-
dc.creatorGurpide, A. (Alfonso)-
dc.creatorLopez-Picazo, J.M. (José M.)-
dc.creatorGonzalez-Hernandez, A. (Alvaro)-
dc.creatorMellado, B. (Begoña)-
dc.creatorMartinez, E. (Esther)-
dc.creatorMoreno, F. (Fernando)-
dc.creatorFont, A. (Albert)-
dc.creatorCalvo-González, A. (Alfonso)-
dc.date.accessioned2014-02-27T08:23:44Z-
dc.date.available2014-02-27T08:23:44Z-
dc.date.issued2014-
dc.identifier.citationPrior C, Pérez-Gracia JL, García-Donas J, Rodríguez-Antona C, Guruceaga E, Esteban E, et al. Identification of tissue microRNAs predictive of sunitinib activity in patients with metastatic renal cell carcinoma. PLoS One. 2014 Jan 24;9(1):e86263es_ES
dc.identifier.issn1932-6203-
dc.identifier.urihttps://hdl.handle.net/10171/35300-
dc.description.abstractWe identified differentially expressed microRNAs in MRCC patients presenting marked sensitivity or resistance to sunitinib. MiR-942 was the best predictor of efficacy. We describe a novel paracrine mechanism through which high miR-942 levels in MRCC cells up-regulates MMP-9 and VEGF secretion to enhance endothelial migration and sunitinib resistance. Our results support further validation of these miRNA in clinical confirmatory studies.es_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Sciencees_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectTissue microRNAses_ES
dc.subjectMetastatic renales_ES
dc.subjectCarcinomaes_ES
dc.titleIdentification of tissue microRNAs predictive of sunitinib activity in patients with metastatic renal cell carcinomaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES

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