Body mass index Disease progression Microarray analysis
Fecha de publicación:
Ribeiro R, Monteiro C, Catalán V, Hu P, Cunha V, Rodríguez A. Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue. BMC Med. 2012 Sep 25;10:108.
Obesity and excess adiposity modified the expression of PP adipose tissue genes to ultimately foster fat mass growth. In patients with prostate cancer the expression profile of PP adipose tissue accounted for hypercellularity and reduced immunosurveillance. Both findings may be liable to promote a favorable environment for prostate cancer progression.