Synthesis and antimycobacterial activity of new quinoxaline-2- carboxamide 1,4-di-N-oxide derivatives.
Keywords: 
Mycobacterium tuberculosis
Anti-tuberculosis agents
N-oxides
Quinoxaline
Issue Date: 
3-Jul-2010
Publisher: 
Elsevier
ISSN: 
0223-5234
Citation: 
Moreno E, Ancizu S, Pérez-Silanes S, Torres E, Aldana I, Monge A. Synthesis and antimycobacterial activity of new quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives. Eur J Med Chem 2010 10;45(10):4418-4426
Abstract
As a continuation of our research and with the aim of obtaining new anti-tuberculosis agents which can improve the current chemotherapeutic anti-tuberculosis treatments, forty-three new quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives were synthesized and evaluated for in vitro anti-tuberculosis activity against Mycobacterium tuberculosis strain H37Rv. Active compounds were also screened to assess toxicity to a VERO cell line. Results indicate that compounds with a methyl moiety substituted in position 3 and unsubstituted benzyl substituted on the carboxamide group provide an efficient approach for further development of anti-tuberculosis agents.

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