Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Monge, A. (Antonio) | - |
dc.creator | Aldana, I. (Ignacio) | - |
dc.creator | Torres, E. (Enrique) | - |
dc.creator | Pérez-Silanes, S. (Silvia) | - |
dc.creator | Ancizu, S. (Saioa) | - |
dc.creator | Moreno-de-Viguri, E. (Elsa) | - |
dc.date.accessioned | 2014-04-12T17:38:49Z | - |
dc.date.available | 2014-04-12T17:38:49Z | - |
dc.date.issued | 2010-07-03 | - |
dc.identifier.citation | Moreno E, Ancizu S, Pérez-Silanes S, Torres E, Aldana I, Monge A. Synthesis and antimycobacterial activity of new quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives. Eur J Med Chem 2010 10;45(10):4418-4426 | es_ES |
dc.identifier.issn | 0223-5234 | - |
dc.identifier.uri | https://hdl.handle.net/10171/35793 | - |
dc.description.abstract | As a continuation of our research and with the aim of obtaining new anti-tuberculosis agents which can improve the current chemotherapeutic anti-tuberculosis treatments, forty-three new quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives were synthesized and evaluated for in vitro anti-tuberculosis activity against Mycobacterium tuberculosis strain H37Rv. Active compounds were also screened to assess toxicity to a VERO cell line. Results indicate that compounds with a methyl moiety substituted in position 3 and unsubstituted benzyl substituted on the carboxamide group provide an efficient approach for further development of anti-tuberculosis agents. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | PIUNA project from University of Navarra. Tuberculosis Antimicrobial Acquisition & Coordinating Facility (TAACF) | - |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Mycobacterium tuberculosis | es_ES |
dc.subject | Anti-tuberculosis agents | es_ES |
dc.subject | N-oxides | es_ES |
dc.subject | Quinoxaline | es_ES |
dc.title | Synthesis and antimycobacterial activity of new quinoxaline-2- carboxamide 1,4-di-N-oxide derivatives. | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1016/j.ejmech.2010.06.036 | es_ES |
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