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dc.creatorPerez-Silanes, S. (Silvia)-
dc.creatorMonge, A. (Antonio)-
dc.creatorAldana, I. (Ignacio)-
dc.creatorGonzalez, M. (Mercedes)-
dc.creatorCerecetto, H. (Hugo)-
dc.creatorDi-Maio, R. (Rossanna)-
dc.creatorBirriel, E. (Estefanía)-
dc.creatorVarela, J. (Javier)-
dc.creatorArbillaga, L. (Leire)-
dc.creatorAzqueta, A. (Amaya)-
dc.creatorCrawford, P.W. (Philip W.)-
dc.creatorDevarapally, G. (Goutham)-
dc.creatorGaliano, S. (Silvia)-
dc.creatorMoreno-Viguri, E. (Elsa)-
dc.creatorTorres, E. (Enrique)-
dc.date.accessioned2014-04-13T11:45:35Z-
dc.date.available2014-04-13T11:45:35Z-
dc.date.issued2013-05-30-
dc.identifier.citationTorres E, Moreno-Viguri E, Galiano S, Devarapally G, Crawford PW, Azqueta A, et al. Novel quinoxaline 1,4-di-N-oxide derivatives as new potential antichagasic agents. Eur J Med Chem 2013 8;66(0):324-334es_ES
dc.identifier.issn0223-5234-
dc.identifier.urihttp://hdl.handle.net/10171/35794-
dc.description.abstractAs a continuation of our research and with the aim of obtaining new agents against Chagas disease, an extremely neglected disease which threatens 100 million people, eighteen new quinoxaline 1,4-di-Noxide derivatives have been synthesized following the Beirut reaction. The synthesis of the new derivatives was optimized through the use of a new and more efficient microwave-assisted organic synthetic method. The new derivatives showed excellent in vitro biological activity against Trypanosoma cruzi. Compound 17, which was substituted with fluoro groups at the 6- and 7-positions of the quinoxaline ring, was the most active and selective in the cytotoxicity assay. The electrochemical study showed that the most active compounds, which were substituted by electron-withdrawing groups,possessed a greater ease of reduction of the N-oxide groupses_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relationFIMA (Fundación para la Investigación Médica Aplicada) from the University of Navarra. CSIC (Comisión de Investigación Científica) from Universidad de la República de Uruguay. Iberoamerican Program for Science and Technology (CYTED), network RIDIMEDCHAG.-
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectReduction potentiales_ES
dc.subjectCytotoxicityes_ES
dc.subjectMutagenicityes_ES
dc.subjectQuinoxaline 1,4-di-N-oxidees_ES
dc.subjectTrypanosoma cruzies_ES
dc.subjectChagas diseasees_ES
dc.titleNovel quinoxaline 1,4-di-N-oxide derivatives as new potential antichagasic agentses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.ejmech.2013.04.065es_ES

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